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Arq. bras. endocrinol. metab ; 53(7): 874-879, out. 2009. ilus, tab
Article in English | LILACS | ID: lil-531702

ABSTRACT

The radioactive iodine has been used with great value as a diagnostic and therapeutic method in patients with differentiated thyroid carcinoma previously submitted to total thyroidectomy. False-positive whole-body scans may occur due to misinterpretation of the physiologic distribution of the radioisotope or lack of knowledge on the existence of other pathologies that could eventually present radioiodine uptake. Thymic uptake is an uncommon cause of false-positive whole-body scan, and the mechanism through which it occurs is not completely understood. The present paper reports five cases of patients with differentiated thyroid cancer who presented a mediastinum uptake of radioiodine in a whole-body scan during follow-up. The patients had either histological or radiological confirmation of the presence of residual thymus gland. It is very important to know about the possibility of iodine uptake by the thymus in order to avoid unnecessary treatment, such as surgery or radioiodine therapy.


O iodo radioativo tem sido utilizado com grande valia como método diagnóstico e terapêutico em pacientes com carcinoma diferenciado de tireoide previamente submetidos à tireoidectomia total. Resultados falso-positivos na pesquisa de corpo inteiro (PCI) podem ocorrer por má interpretação da distribuição fisiológica do radioisótopo ou por não conhecimento da existência de outras patologias que podem eventualmente captar o radioiodo. Captação pelo timo é uma causa incomum de resultado falso-positivo e o mecanismo pelo qual ocorre não é totalmente esclarecido. O presente trabalho relata cinco casos que apresentaram PCI positiva em mediastino durante o seguimento, com comprovação histológica ou tomográfica sugestiva de timo. Ressalta-se a importância do conhecimento dessa possível causa de falso-positivo a fim de se evitar tratamentos desnecessários.


Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Carcinoma , Iodine Radioisotopes/pharmacokinetics , Mediastinal Neoplasms , Thymus Gland/metabolism , Thyroid Neoplasms/metabolism , Carcinoma/metabolism , Carcinoma/radiotherapy , False Positive Reactions , Iodine Radioisotopes , Iodine Radioisotopes/therapeutic use , Mediastinal Neoplasms/secondary , Thymus Gland , Thyroid Neoplasms , Thyroid Neoplasms/radiotherapy , Whole Body Imaging
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